Yes. The following substances may be incompatible with bead-based multiplex assays or may interfere with assay performance:
- Heparin: Heparin should not exceed 10 IU per mL of sample. It can cause bead agglutination and increased signals.
- DMSO and similar organic solvents: DMSO and other similar organic solvents may cause the leaching of dye from the beads, making sample analyte levels undetectable.
- SDS and similar denaturing agents: SDS and other similar denaturing agents should not exceed 0.1% in the sample. These reagents can cause improper capturing of analytes.